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目的探讨视网膜母细胞瘤（ｒｅｔｉｎｏｂｌａｓｔｏｍａ，ＲＢ）脉络膜浸润的组织学分期及与预后的关系。方法光镜下复习观察１９８５年６月到１９９５年６月期间２９７只ＲＢ眼摘除眼球的组织病理切片。为估量此病患者预后的危险因素，着重对患眼脉络膜浸润进行分级，并对患者进行随访。结果根据肿瘤细胞对眼内组织结构的影响，以脉络膜为中心将其分为５期：０期：视网膜色素上皮反应前期（１４４／２９７，４８．４８％）；Ⅰ期：视网膜色素上皮反应期（８１／２９７，２７．２７％）；Ⅱ期：脉络膜浸润早期（２９／２９７，９．７６％）；Ⅲ期：脉络膜浸润中期（１７／２９７，５．７２％）；Ⅳ期：脉络膜浸润晚期（２６／２９７，８．７５％）。Ⅱ～Ⅳ期为脉络膜浸润期。２４．２４％的切片中发现有脉络膜浸润。患者经平均５１．８个月的随访，０～Ⅲ期的患者死亡率为０．４％，Ⅳ期患者为１２．０％。结论脉络膜浸润晚期（大范围的脉络膜浸润）肿瘤细胞转移率较高，患者预后差。
Objective To investigate the histological staging of retinoblastoma (RB) choroidal infiltration and its relationship with prognosis. Methods The histopathological sections of 297 RB eyes were enucleated from 1985 to June 1995. In order to estimate the risk factors for the prognosis of this patient, the choroidal infiltration in affected eyes was grading and the patients were followed up. RESULTS: According to the influence of tumor cells on the intraocular tissue structure, the choroid was taken as the center and divided into 5 phases: 0 phase: the early stage of retinal pigment epithelium reaction (144/297, 48.48%); phase I: retinal pigment epithelium reaction phase (81/297, 27.27%); Phase II: Early stage of choroidal invasion (29/297, 9.76%); Stage III: Intermediate stage of choroidal invasion (17/297, 5.72%); Stage IV: Choroidal invasion Late (26/297, 8.75%). Stage II-IV is choroidal infiltration. Choroidal infiltrate was found in 24.24% of the sections. After a mean follow-up of 51.8 months, the mortality rate was 0.4% for patients with stage 0-III and 12.0% for patients with stage IV. Conclusions Late metastatic choroidal invasion (large choroidal infiltration) has a high metastasis rate and poor prognosis.