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目的:丹红注射液联合单硝酸异山梨酯缓释片治疗老年冠心病,研究其临床疗效并对其安全性做出评价。方法:80例老年冠心病患者随机分为两组,治疗组及对照组各40例。两组患者均口服给予患者单硝酸异山梨酯缓释片进行治疗,治疗组在此基础上静脉滴注丹红注射液。治疗期间停用降血脂药物。结果:丹红注射液联合单硝酸异山梨酯缓释片治疗老年冠心病治疗效果、心电图疗效比较均优于对照组,有显著性差异(P<0.05)。和治疗前相比,治疗后两组患者胆固醇及三酰甘油含量均显著性降低(P<0.05);治疗后,和对照组相比,治疗组胆固醇及三酰甘油含量显著降低(P<0.05)。治疗组患者不良反应明显低于对照组,有显著性差异(P<0.05)。结论:与单独给予单硝酸异山梨酯缓释片相比,联合应用丹红注射液治疗效果明显提高,胆固醇及三酰甘油含量显著降低,副反应小,更适合临床推广。
Objective: Danhong injection combined with isosorbide mononitrate sustained-release tablets in the treatment of elderly patients with coronary heart disease, to study its clinical efficacy and to evaluate its safety. Methods: Eighty elderly patients with coronary heart disease were randomly divided into two groups, the treatment group and the control group of 40 cases. Patients in both groups were given oral isosorbide mononitrate sustained-release tablets for treatment, the treatment group on the basis of intravenous infusion of Danhong injection. Disable lipid-lowering drugs during treatment. Results: Danhong injection combined with isosorbide mononitrate sustained-release tablets in the treatment of elderly patients with coronary heart disease, ECG efficacy were better than the control group, there was a significant difference (P <0.05). Compared with those before treatment, the levels of cholesterol and triglyceride in the two groups were significantly decreased after treatment (P <0.05), and the levels of cholesterol and triglyceride in the treatment group were significantly lower than those in the control group after treatment ). Adverse reactions in treatment group were significantly lower than those in control group, with significant difference (P <0.05). Conclusion: Compared with the administration of isosorbide mononitrate sustained-release tablets alone, the combined application of Danhong injection significantly improved the effect of treatment, cholesterol and triglyceride content was significantly reduced, the side effects of small, more suitable for clinical promotion.