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目的探讨狼疮肾炎(lupus nephritis,LN)患者尿液中单核细胞趋化因子1(monocyte chemoattractant protein 1,MCP-1)的水平及其临床意义。方法采用横断面调查研究分析方法,ELISA法检测33例活动期狼疮肾炎患者和35例缓解期狼疮肾炎患者尿液中MCP-1水平。结果活动期狼疮肾炎患者MCP-1水平[468.0(205～1 990)pg/mg Cr]明显高于缓解期狼疮肾炎患者[131.5(69～734)pg/mg Cr],差异有统计学意义(P=0.000)。活动期狼疮肾炎组患者年龄(25.9±3.7)岁,缓解期狼疮肾炎组患者年龄(29.7±3.5)岁,两组年龄有统计学差异(P<0.05),活动期狼疮肾炎组患者抗ds-DNA抗体阳性率高于缓解期狼疮肾炎组患者(P<0.05)。两组在性别和族别上无统计学差异(P>0.05)。活动期狼疮肾炎组患者尿液中MCP-1水平与24h尿蛋白定量及24h尿白蛋白/肌酐(Urinary albumin-to-creatinine,UACR)呈正相关(r=0.916,P=0.000;r=0.936,P=0.000)。结论活动期狼疮肾炎患者尿液中MCP-1水平升高,对狼疮肾炎的活动性及复发具有可靠稳定的临床诊断意义。需进行前瞻性研究进一步明确其临床意义。
Objective To investigate the level of urine monocyte chemoattractant protein 1 (MCP-1) in patients with lupus nephritis (LN) and its clinical significance. Methods The cross-sectional investigation and analysis methods were used. The levels of MCP-1 in urine of 33 patients with active lupus nephritis and 35 patients with remission lupus nephritis were detected by ELISA. Results The level of MCP-1 in patients with active lupus nephritis [468.0 (205-190) pg / mg Cr] was significantly higher than that in patients with remission lupus nephritis [131.5 (69-734 pg / mg Cr] P = 0.000). The active age of patients with lupus nephritis (25.9 ± 3.7) years of age, remission lupus nephritis patients age (29.7 ± 3.5) years, the two groups were statistically significant differences in age (P lt; 0.05) The positive rate of DNA antibody was higher than that in remission lupus nephritis group (P <0.05). There was no significant difference in gender and ethnicity between the two groups (P> 0.05). The level of MCP-1 in urine of active lupus nephritis patients was positively correlated with 24-hour urinary protein and urinary albumin-to-creatinine (UACR) (r = 0.916, P = 0.000; r = 0.936, P = 0.000). Conclusions The level of MCP-1 in the urine of active lupus nephritis patients is elevated, which has a reliable and stable clinical diagnostic significance for the activity and recurrence of lupus nephritis. Need to conduct prospective studies to further clarify its clinical significance.