【摘 要】
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目的 探讨酒精性脂肪性肝病(AFLD)与颈动脉内膜中层厚度(CIMT)的关系及其影响因素.方法 从2012年1月-2013年12月在山东省泰山医院住院及查体人群中选取饮酒男性136例和无饮酒
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目的 探讨酒精性脂肪性肝病(AFLD)与颈动脉内膜中层厚度(CIMT)的关系及其影响因素.方法 从2012年1月-2013年12月在山东省泰山医院住院及查体人群中选取饮酒男性136例和无饮酒史男性11例作为研究对象进行横断面研究.将其分为:轻度AFLD组(A组)45例;中重度AFLD组(B组)58例;无脂肪肝组(C组)44例.多个样本的均数比较采用单因素方差分析,两两比较若方差齐则采用LSD检验,若方差不齐则采用Tamhanes检验.结果 (1)B组人群CIMT明显高于C组(P=0.001).(2)A组人群身体质量指数(BMI)明显高于C组(P=0.029).A组和B组人群胆固醇(TC)、甘油三酯(TG)、极低密度脂蛋白(VLDL)、载脂蛋白(Apo)B和血尿酸(UA)均明显高于C组(P值均＜0.05).(3)A组人群GGT明显高于C组(P =0.001).B组人群ALT、AST和GGT均明显高于C组(P值分别为0.023、0.003和0.000).(4)A组和B组人群血肌酐(Cr)均明显低于C组(P值分别为0.007和0.005).结论 AFLD可导致CIMT增厚,引起产生类代谢综合征样改变及肝肾功能异常,并且随着AFLD程度的加重,CIMT增厚更加明显,因此AFLD可用来作为预测人群发生CIMT增厚的指标.
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