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背景 输血中净化血液的新型PEN110化学处理方法包括处理少白细胞红细胞,可采用PEN110对广谱的病原体进行灭活。经洗涤的红细胞制剂含有低于0.00005mg/mL的残余PEN110,重要的是要证实血液中的微量残余PEN110不会影响生殖、生育力或胎儿发育。设计与方法 雄性和雌性Sprague-Dawley大鼠静脉注射0.5mg/公斤体重以上的PEN110,根据随后按标准规程进行的原始记录开展生育力和早期胚胎发育的研究。胎儿发育的研究是根据妊娠Hra:(NZW)SPF兔静脉注射每公斤体重1.0mgPEN110以后的标
Background The new PEN110 chemical treatment for blood purification in transfusions involves the treatment of leukocyte-depleted red blood cells that can be deactivated with PEN110 for a broad spectrum of pathogens. The washed erythrocyte formulation contains less than 0.00005 mg / mL of residual PEN110 and it is important to verify that trace amounts of residual PEN110 in the blood do not affect reproductive, fertility or fetal development. Design and Methods Male and female Sprague-Dawley rats were intravenously injected with 0.5 mg / kg body weight of PEN110 and fertility and early embryonic development was studied on the basis of subsequent original records following standard protocols. Fetal development is based on pregnancy Hra: (NZW) SPF rabbit intravenous injection of 1.0mgPEN110 per kilogram of body weight after the standard