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背景:炎症性肠病(IBD)是一种慢性非特异性肠道炎症性疾病,其发病机制尚未明确。最新的研究发现特异性的microRNA可以用来精确发现炎症性肠病的发生并判断预后。然而,不同的研究得到的结果并不一致。目的:通过综合不同研究的结果得到在炎症性肠病中差异表达的microRNA。方法:采用meta分析回顾已发表的比较炎症性肠病肠道组织与正常人的肠道组织microRNA表达差异的文献,根据这些研究中交叉的部分识别候选microRNA,通过得到的重复的结果可以提高研究的可靠性和降低错误。结果:最终有19篇比较炎症性肠病肠道组织与正常肠道组织的microRNA表达分析的文献符合纳入标准,其中包含了26个研究,共报道211个microRNA,有41个microRNA在至少2个研究中被报道。在溃疡性结肠炎和克罗恩病的亚群分析中,4个microRNA(miR-21、miR-31、miR-146a、miR-223)在这两种疾病中均一致上调。未有溃疡性结肠炎和克罗恩病中均一致下调的microRNA。结论:有数个microRNA在炎症性肠病的研究中有一致的改变,这些microRNA在炎症性肠病的诊断、预后、治疗方面可能具有较大的临床应用潜力。
Background: Inflammatory bowel disease (IBD) is a chronic, nonspecific intestinal inflammatory disease whose pathogenesis is unclear. The latest study found that specific microRNA can be used to accurately detect the occurrence of inflammatory bowel disease and determine the prognosis. However, the results obtained by different studies are not consistent. OBJECTIVE: To generate microRNAs differentially expressed in inflammatory bowel disease by synthesizing the results of different studies. METHODS: A meta-analysis of published literature comparing differences in microRNA expression in gut tissue between inflammatory bowel disease and normal individuals was performed. Based on cross-sectional identification of candidate microRNAs in these studies, repeated studies were conducted Reliability and reduce errors. RESULTS: In the end 19 articles that compared microRNA expression analysis of intestinal tissue with normal intestinal tissue with inflammatory bowel disease met the inclusion criteria, including 26 studies covering a total of 211 microRNAs and 41 microRNAs in at least 2 The study was reported. Four microRNAs (miR-21, miR-31, miR-146a, miR-223) were consistently up-regulated in both disease in a subset analysis of ulcerative colitis and Crohn’s disease. No microRNAs consistently down-regulated in ulcerative colitis and Crohn’s disease. Conclusions: Several microRNAs have been consistently altered in the study of inflammatory bowel disease, and these microRNAs may have potential for clinical application in the diagnosis, prognosis and treatment of IBD.