论文部分内容阅读
目的:探讨头颈部侵袭性纤维瘤病的临床表现、病理特征、治疗方式及预后,为临床医生正确诊治及降低该病复发率提供帮助。方法:回顾性分析2例头颈部侵袭性纤维瘤病的临床资料并复习相关文献。结果:侵袭性纤维瘤病以浸润性生长、局部易复发及无远处转移为特点。病理学表现为成纤维细胞单克隆增生,由分化良好的成纤维细胞和肌成纤维细胞组成,无恶性细胞学特征和有丝分裂相。本组患者中1例第1次手术后复发,再次手术后随访6个月无复发;另1例手术后随访6个月未复发。结论:头颈部侵袭性纤维瘤病症状无特异性,诊断主要依靠术后病理,彻底手术切除是治疗并减少复发的主要手段。对于复发或难以完整切除的患者,可配合放化疗。
Objective: To investigate the clinical manifestations, pathological features, treatment and prognosis of head and neck invasive fibromatosis and to provide help to clinicians in correctly diagnosing and reducing the recurrence rate. Methods: A retrospective analysis of 2 cases of head and neck invasive fibromatosis clinical data and review the relevant literature. Results: Invasive fibromatosis was characterized by invasive growth, local recurrence and distant metastasis. Pathological manifestations of fibroblast monoclonal proliferation, from well-differentiated fibroblasts and myofibroblasts, no malignant cytology and mitotic phase. One patient in this group of patients relapsed after the first operation, no recurrence after 6 months of follow-up operation; the other one case did not recur after 6 months of follow-up. Conclusion: There are no specific symptoms of head and neck invasive fibromatosis. The diagnosis mainly depends on the postoperative pathology. Complete surgical resection is the main method to treat and reduce recurrence. For patients with recurrent or difficult to complete resection, with radiotherapy and chemotherapy.