服乙双吗啉后发生急性白血病5例

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病历摘要例1 男,28岁。半年前患银屑病,服乙双吗啉约100克。每次服一片,每天三次,连续服一个多月。一个月前因粒细胞减少住某院。近4天发热、鼻衄、全血细胞减少,并发现幼稚细胞转我院。既往健康,无其它特殊药物及毒物接触史,体温37.9℃,贫血貌,皮肤散在瘀血斑点及银屑皮损,表浅淋巴结不大,胸骨明显压痛,肝脾无肿大,血红蛋白45g/L,白细胞为1.2×10~9/L,血小板6×10~9/L, 网织红细胞0.08%,幼稚细胞36%;骨髓增生活跃,单核系异常增生,原单+幼单为65%,粒系、红系均受抑,全片未找到巨核细胞,血小板少见,符合急性单核细胞白血病(M 5)。入院后给予输血、抗感染及止血剂治疗3天,病人自动出院。例2 女,37岁,农民。2年前因患银屑病服乙双吗啉治疗,每次一片,每日 Case history 1 male, 28 years old. Six months ago suffering from psoriasis, serving B double morpholine about 100 grams. Take one tablet at a time, three times a day for more than a month. A month ago due to neutropenia to live in a hospital. Nearly 4 days fever, epistaxis, pancytopenia, and found that naive cells to our hospital. Previous health, no other special drugs and toxic contact history, body temperature 37.9 ℃, anemic appearance, the skin scattered in the bleeding spots and silver skin lesions, superficial lymph nodes, tender tenderness of the sternum, liver and spleen no swelling, hemoglobin 45g / L , Leukocytes 1.2 × 10 ~ 9 / L, platelets 6 × 10 ~ 9 / L, reticulocyte 0.08%, immature cells 36%; bone marrow hyperplasia, mononuclear dysplasia, the original single + Department, red line were suppressed, the whole film did not find megakaryocytes, rare platelets, in line with acute monocytic leukemia (M 5). After admission to give blood transfusion, anti-infection and hemostatic agents for 3 days, the patient was discharged. Example 2 Female, 37 years old, farmer. 2 years ago due to suffering from psoriasis B-morphine treatment, one at a time, daily
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