【摘 要】
：
目的研究持续压力对体外培养大鼠成骨细胞碱性磷酸酶分泌活性的影响. 方法利用自行研制的细胞加力装置给大鼠成骨细胞施加不同大小的静压力,观察加力不同时程后的碱性磷酸酶
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目的研究持续压力对体外培养大鼠成骨细胞碱性磷酸酶分泌活性的影响. 方法利用自行研制的细胞加力装置给大鼠成骨细胞施加不同大小的静压力,观察加力不同时程后的碱性磷酸酶分泌活性.结果加力后成骨细胞碱性磷酸酶分泌活性降低,停止加力后24 h碱性磷酸酶的分泌活性在3×105 Pa组恢复正常,而在4×105 Pa和5×105 Pa组未完全恢复.结论持续压力可降低成骨细胞碱性磷酸酶的分泌活性,适当力值的压力在恢复正常后碱性磷酸酶的分泌活性可恢复正常,力值过大则可能影响细胞的功能.
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