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本文用阿拉伯胶、聚乙烯二醇与难溶性药物硝酸山棃醇酯(ISDN)混合,制成单室的渗透泵型片剂,方法简便.在胃肠道中,水恒速地穿透膜而达制剂片心,使阿拉伯胶等溶解,药物成为混悬液,由于渗透压较大而将ISDN混悬液从小孔中压出.兹从12个处方中举出一例说明其制法和释药特性:阿拉伯胶100份、滑石粉3.2份,混匀作赋形剂.每片含赋形剂280mg,ISDN 20mg,混匀,直接压片,弧形冲头,直径6mm,此即片心.醋酸纤维素、Eudragit S100与聚乙烯二醇15000(1.0∶0.9∶1.2)的混合物溶于丙酮-乙醇混合溶剂中,作包衣膜用,将此液喷于片心表面,溶剂挥发后即成渗透膜.40℃干燥15h,膜厚为50～70μm,用热金属丝钻孔,孔经为830～860μm.在体外试验中表明ISDN呈零级速度释放.若小孔孔径>1400μm,则释药太快;若孔径小至300μm,则ISDN混悬液压不出来.当孔径830～860μm,膜厚50
In this paper, acacia, polyethylene glycol and poorly soluble drug behenate nitrate ester (ISDN) mixed to make single-chamber osmotic pump tablets, the method is simple in the gastrointestinal tract, the water penetrates the membrane at a constant speed Up to the center of the preparation, the gum arabic dissolved, the drug into a suspension, the osmotic pressure will be ISDN suspension from the hole out of pressure from the 12 prescriptions cited an example of its preparation and release Medicine characteristics: 100 parts of acacia gum, 3.2 parts of talcum powder, mix as excipient, each tablet contains excipient 280mg, ISDN 20mg, mix, direct compression, arc punch, diameter 6mm, . A mixture of cellulose acetate, Eudragit S100 and polyethylene glycol 15000 (1.0: 0.9: 1.2) was dissolved in acetone-ethanol mixed solvent and used as a coating film. This solution was sprayed on the surface of the pellet, Into an osmotic membrane.40 ℃ drying 15h, the film thickness of 50 ~ 70μm, with hot wire drilling, the hole by the 830 ~ 860μm in vitro test showed that ISDN zero-speed release.If the aperture of> 1400μm, then Drug release is too fast; if the pore size is as small as 300μm, then the ISDN suspension pressure does not come out when the aperture 830 ~ 860μm, film thickness 50