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自从Powell .R.G.发表他从三尖杉属植物中分离得到微量的抗白血病的生物碱以来,生物碱的合成研究,顿时引起了许多著名的有机化学家的极大兴趣。兰州大学黄文魁教授等合成了一系列的生物碱类衍生物,工作相当突出,受到了国家奖励。然而,草酸单乙酯粗榧酯碱正是合成这类结构复杂、生理活性强的天然生物碱的起始原料,亦为在人工合成的化学结构中引入天然粗榧母核的关键中间体。过去曾有美国人
Since the publication by Powell .R.G. of his isolation of trace amounts of leukemia-resistant alkaloids from the genus Cephalotaxus, the synthesis of alkaloids has suddenly attracted the attention of many well-known organic chemists. Lanzhou University, Professor Huang Wenkui synthesized a series of alkaloid derivatives, work is quite prominent, has been the national award. However, crude ethyl ester of monoethyl oxalate is the starting material for the synthesis of such natural alkaloids with complex structure and strong physiological activity. It is also the key intermediate for the introduction of crude crude parent nucleus into the chemical structure of artificial synthesis. There used to be Americans