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目的探讨阿司匹林联合氯吡格雷治疗不稳定型心绞痛患者的临床疗效。方法选取2013年5月至2015年1月辽宁省海城市中医院收治的100例不稳定型心绞痛患者为研究对象,按随机数字表法分为对照组和观察组,每组50例。对照组患者根据常规心内科标准用药,观察组患者采用阿司匹林联合氯吡格雷方案治疗,连续治疗8周后,比较两组患者的治疗效果。结果观察组患者治疗后的临床总有效率达94.0%(47/50),明显高于对照组的80.0%(40/50),差异有统计学意义(P<0.05);观察组患者的症状发作频率明显较对照组少,每次持续时间更短,各项心功能指标改善更显著,差异均有统计学意义(均P<0.05)。治疗期间,两组患者均未发生严重不良反应。结论采用阿司匹林联合氯吡格雷方案治疗不稳定型心绞痛患者临床疗效好、安全可行,且可有效减轻患者的症状、促进心功能恢复。
Objective To investigate the clinical efficacy of aspirin plus clopidogrel in patients with unstable angina pectoris. Methods From May 2013 to January 2015, 100 patients with unstable angina pectoris in Haicheng Hospital of Traditional Chinese Medicine from May 2013 to January 2015 were divided into control group and observation group according to random number table method, with 50 cases in each group. Patients in the control group were treated according to the standard cardiology standards. The patients in the observation group were treated with aspirin plus clopidogrel. After 8 weeks of continuous treatment, the treatment effect was compared between the two groups. Results The total effective rate of the observation group after treatment was 94.0% (47/50), which was significantly higher than that of the control group (80.0%, 40/50), the difference was statistically significant (P <0.05) The seizure frequency was significantly less than that of the control group, with shorter duration and more significant improvement of each cardiac function index (all P <0.05). During treatment, no serious adverse reactions occurred in both groups. Conclusion Aspirin combined with clopidogrel in patients with unstable angina pectoris has good clinical efficacy and is safe and feasible. It can effectively alleviate the symptoms and promote the recovery of cardiac function.