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原发性肝癌居所有常见恶性肿瘤第6位,死亡率高居第3位[1-3]。我国肝癌发病率为28.71/105,占所有恶性肿瘤的第4位(10.04%);死亡率居第2位(14.42%)[4]。由于肝癌发病隐匿、早期诊断困难、癌细胞生长迅速等特点,导致大多数病人确诊时已属晚期,手术切除率<30%[5]。目前临床应用的化疗、消融及肝动脉栓塞术等治疗具有一定的适应证,肿瘤残留与复发严重影响疗效。因此,深入研究肝癌发生、发展的
Primary liver cancer ranks sixth in all common malignancies with the highest mortality rate [1-3]. The incidence of liver cancer in China was 28.71 / 105, accounting for the fourth (10.04%) of all malignant tumors; the mortality rate ranked the second (14.42%) [4]. Due to the occult onset of HCC, difficulties in early diagnosis and the rapid growth of cancer cells, the majority of patients are already diagnosed with advanced disease and the rate of resection is less than 30% [5]. The current clinical application of chemotherapy, ablation and hepatic artery embolization and other treatment has some indications, residual tumor and recurrence seriously affect the efficacy. Therefore, in-depth study of the occurrence and development of liver cancer