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目的:探讨乌司他丁联合去甲肾上腺素治疗感染性休克的疗效观察及对患者血清炎性因子的影响。方法:采用随机数字表法将2019年1月至2020年2月台州市中心医院收治的感染性休克患者84例分为观察组和对照组，各42例，在常规治疗基础上，对照组给予去甲肾上腺素持续静脉滴注，观察组给予乌司他丁联合去甲肾上腺素治疗；观察比较两组患者临床疗效、治疗前后血清炎性因子、血流动力学指标的变化情况。结果:观察组治疗总有效率（90.48%，38/42）高于对照组（69.05%，29/42）（χn 2=5.974，n P<0.05）；观察组治疗后血清肿瘤坏死因子α［（26.27±3.15）mg/L］、白细胞介素8［（73.47±6.35）ng/L］、超敏C反应蛋白［（69.38±5.58）mg/L］均低于对照组［（37.29±3.24）mg/L、（95.28±6.33）ng/L、（87.54±5.63）mg/L］（n t=15.804、15.764、14.847，均n P<0.05）；观察组治疗后心率［（86.38± 8.56）次/min］低于对照组［（93.64±8.25）次/min］，而平均动脉压［（77.15±5.31）mmHg］和氧合指数［（222.01±16.32）mmHg］均高于对照组［（70.23±5.25）mmHg、（203.31±16.17）mmHg］，均差异有统计学意义（n t=3.958、6.006、5.275，均n P<0.05）；观察组治疗后脓毒症相关性器官功能衰竭评分［（8.69± 1.42）分］、急性生理与慢性健康状况评分［（15.84±3.88）分］均低于对照组［（10.38±2.16）分、（20.79±4.07）分］（n t=4.237、5.705，均n P<0.05）。n 结论:乌司他丁联合去甲肾上腺素治疗感染性休克疗效可靠，可有效抑制机体炎性反应，促进患者血流动力学稳定。“,”Objective:To investigate the efficacy of ulinastatin combined with norepinephrine in the treatment of septic shock and its effect on serum inflammatory factors.Methods:Eighty-four patients with septic shock who received treatment in Taizhou Central Hospital from January 2019 to February 2020 were included in this study. These patients were randomly assigned to receive intravenous administration of norepinephrine (control group, n n = 42) or treatment with ulinastatin combined with norepinephrine (observation group, n n = 42) based on conventional treatment. Clinical efficacy, serum inflammatory factors and hemodynamic indexes before and after treatment were compared between the control and observation groups.n Results:Total effective rate in the observation group was significantly higher than that in the control group [90.48% (38/42) n vs. 69.05%, 29/42, χn 2= 5.974, n P < 0.05]. Serum tumor necrosis factor α [(26.27 ± 3.15) mg/L n vs. (37.29 ± 3.24) mg/L, n t = 15.804, n P < 0.05], interleukin-8 [(73.47 ± 6.35) ng/L n vs. (95.28 ± 6.33) ng/L, n t = 15.764, n P < 0.05], and high-sensitivity C-reactive protein [(69.38 ± 5.58) mg/L n vs. (87.54 ± 5.63) mg/L, n t = 14.847, n P < 0.05] levels were significantly lower compared with the control group. Heart rate in the observation group was significantly lower than that in the control group [(86.38 ± 8.56) beats/min n vs. (93.64 ± 8.25) beats/min, n t = 3.958, n P < 0.05). The mean arterial pressure [(77.15 ± 5.31) mmHg n vs. (70.23 ± 5.25) mmHg, n t = 6.006, n P < 0.05] and oxygenation index [(222.01 ± 16.32) mmHg n vs. (203.31 ± 16.17) mmHg, n t = 5.275, n P < 0.05] were significantly higher compared with the control group. Sepsis-related organ failure assessment score [(8.69 ± 1.42) points n vs. (10.38 ± 2.16) points, n t = 4.237, n P < 0.05] and acute physiology and chronic health evaluation score [(15.84 ± 3.88) points n vs. (20.79 ± 4.07) points, n t = 5.705, n P < 0.05] were significantly lower compared with the control group.n Conclusion:Ulinastatin combined with norepinephrine is effective in the treatment of septic shock, which can effectively inhibit the inflammatory reaction and promote the stability of hemodynamics.