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1病例报告患者男,46岁。因体检发现血脂增高1周就诊。查体:无阳性体征。血生化检查:总胆固醇7.26mmol/L,三酰甘油2.56mmol/L,余无特殊。诊断为高脂血症。给予洛伐他汀胶囊20mg,每天晚饭时服。连续服用13天后出现双下肢肌肉酸痛,继而全身肌肉酸痛,不能行走。急查磷酸肌酸激酶,与用药前比较无明显升高。考虑洛伐他汀致弥漫性肌痛,遂立即停用洛伐他汀,7天后全身肌肉酸痛症状消失。
A case report male patient, 46 years old. Because of physical examination found that increased blood lipid 1 week treatment. Physical examination: no positive signs. Blood biochemical tests: total cholesterol 7.26mmol / L, triglyceride 2.56mmol / L, I no special. Diagnosis of hyperlipidemia. Lovastatin capsules 20mg, daily supper when serving. After taking 13 consecutive days of double lower extremity muscle soreness, followed by muscle aches and pains, can not walk. Urgent search of creatine kinase, no significant increase compared with before treatment. Considering lovastatin-induced diffuse myalgia, lovastatin was stopped immediately and symptoms of generalized muscle aches disappeared after 7 days.