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目的:研究livin蛋白在非小细胞肺癌中的表达及其与非小细胞肺癌的生物学特性及临床预后的关系。方法:通过免疫组化的方法检测和比较88例非小细胞肺癌组织和20例癌旁正常肺组织中livin蛋白的表达,并分析其与非小细胞肺癌的临床病理特征和预后的相关性。结果:非小细胞肺癌组织及癌旁正常肺组织中livin蛋白的阳性表达率分别为54.55%和5%,差异有显著统计学差异(P<0.05)。非小细胞肺癌组织中livin蛋白的表达水平与淋巴结转移、TNM分期显著相关(P<0.05),但与患者的性别、年龄、分化程度及病理学类型无关(P>0.05)。Livin高表达的非小细胞肺癌患者生存时间显著短于livin低表达的患者(P<0.05)。结论:Livin蛋白在非小细胞肺癌的发生及发展中起重要作用并与患者的预后相关,可能作为非小细胞肺癌新的防治靶点。
Objective: To investigate the expression of livin protein in non-small cell lung cancer and its relationship with the biological characteristics and clinical prognosis of non-small cell lung cancer. Methods: The expressions of livin protein in 88 non-small cell lung cancer tissues and 20 adjacent normal lung tissues were detected by immunohistochemistry and their correlations with clinicopathological characteristics and prognosis of non-small cell lung cancer were analyzed. Results: The positive expression rates of livin protein in non-small cell lung cancer tissues and adjacent normal lung tissues were 54.55% and 5%, respectively, with significant difference (P <0.05). The expression level of livin in non-small cell lung cancer was significantly correlated with lymph node metastasis and TNM stage (P <0.05), but not with gender, age, differentiation and pathological type (P> 0.05). The survival time of Livin-overexpressing NSCLC patients was significantly shorter than that of low-livin patients (P <0.05). Conclusion: Livin protein plays an important role in the occurrence and development of non-small cell lung cancer and is related to the prognosis of patients. It may serve as a new target for prevention and treatment of non-small cell lung cancer.