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慢性铍肺病人和有肺部病变的铍作业工人的淋巴细胞在体外经铍刺激后,可使活性玫瑰花形成率增高。加入铍浓度以0.75微克/毫升最好,孵育时间以37℃2小时为佳。甲厂慢性铍肺病人的平均激活率为23.3%;有肺部病变的铍作业工人组为18.9%;无肺部改变的铍作业工人组和非铍作业对照组无增高现象。将BeEa结果以阳性(激活率≥19%)、可疑阳性(激活率为14～18%)和阴性(激活率<14%)来表示,则5名慢性链肺病人有4名阳性;38名有肺部病变的敛作业工人中有20名阳性和7名可疑阳性;而无肺部病变的铍作业工人29人,非铍作业正常人34人和矽肺、矽肺结核病人25人,全部阴性。乙厂16名有肺部病变的铍作业工人的试验结果与甲厂相似。结果表明,BeEa试验可作为慢性铍肺的辅助诊断和鉴别诊断指标之一。
Lymphocytes from patients with chronic beryllium lung and beryllium workers with lung disease may be stimulated with beryllium in vitro to increase the rate of active rose formation. Beryllium was added at a concentration of 0.75 μg / ml, preferably at 37 ° C for 2 hours. The average activation rate of patients with chronic beryllium lungs in factory A was 23.3%, that of beryllium workers with lung diseases was 18.9%, and there was no increase in beryllium workers and non-beryllium workers without lung changes. The BeEa results were positive (activation rate ≥ 19%), suspicious positive (activation rate 14 ~ 18%) and negative (activation rate <14%) to indicate that 5 out of 4 patients with chronic lung disease were positive; 38 There were 20 positive and 7 suspicious positive workers who had lung diseases, 29 beryllium workers without lung diseases, 34 normal non-beryllium workers, and 25 silicosis patients and 25 silicosis patients, all of whom were negative. Plant B 16 beryllium workers with lung disease test results and a similar factory. The results show that, BeEa test can be used as a chronic beryllium lung diagnosis and differential diagnosis of indicators.