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目的:探讨年轻女性体外受精-胚胎移植(IVF-ET)长方案周期累积活产率的影响因素。方法:回顾性分析首次接受IVF长方案助孕治疗的1 147例年轻且卵巢储备功能良好的不孕女性的临床资料,按完成一次取卵周期是否获得最终活产胎儿分为活产组与未获活产组,采用多因素Logistic回归分析影响累积流产率的相关因素。结果:活产组患者的体质量指数(BMI)较未获活产组显著降低(P<0.05),而获卵数、正常受精率及可移植胚胎数显著增高(P<0.05)。Logistic回归分析显示BMI及可移植胚胎数是年轻且卵巢储备功能良好的不孕女性首次行IVF长方案周期获得累积活产的重要影响因素,BMI<24.2 kg/m2及可移植胚胎数≥5患者的妊娠结局较佳。结论:年轻且卵巢储备功能良好的女性首次IVF长方案周期中,BMI及可移植胚胎数与累积活产率显著相关,较低的BMI及适当多的可移植胚胎数可提高一次取卵周期的累积活产率。
Objective: To investigate the influencing factors of long-term cumulative live birth rate (IVF-ET) in young women with IVF-ET. Methods: The clinical data of 1 147 young and well-preserved infertile women with ovarian reserve who underwent IVF long-term convalescent treatment were retrospectively analyzed. According to whether the fetus with the final live fetus was divided into the live births group The live birth group, multivariate logistic regression analysis of factors affecting cumulative abortion rate. Results: The body mass index (BMI) in the live births group was significantly lower than that in the live births (P <0.05), while the number of oocytes retrieved, the normal fertilization rate and the number of transplantable embryos were significantly increased (P <0.05). Logistic regression analysis showed that the number of BMIs and transplantable embryos was the first important factor influencing cumulative live births in young and well-preserved ovarian reserve women with IVF long-term program cycles. The BMI <24.2 kg / m2 and the number of transplantable embryos≥5 The pregnancy outcome is better. CONCLUSIONS: In young women with good ovarian reserve, the number of BMIs and transplantable embryos was significantly associated with cumulative live births during the first IVF long program cycle. Lower BMIs and the appropriate number of transplantable embryos increased the frequency of ovulation cycles Cumulative live birth rate.