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目的:观察口服药控制不佳的2型糖尿病患者加用地特胰岛素或甘精胰岛素的疗效对比。方法:选取80例口服药控制不佳的2型糖尿病患者,随机分为2组,在原有口服药的基础上,一组(治疗组)睡前注射地特胰岛素,另一组(对照组)睡前注射甘精胰岛素,观察12周。结果:FBG、2hPG和HbA1c下降,在血糖达标所需时间、每天胰岛素用量及低血糖发生率方面,2组间比较无显著性差异(P>0.05)。结论:地特胰岛素与甘精胰岛素在控制2型糖尿病血糖方面同样安全、有效。
OBJECTIVE: To observe the curative effect of dextrose insulin or insulin glargine in type 2 diabetic patients with poor oral control. Methods: Eighty patients with type 2 diabetes with poor oral control were randomly divided into 2 groups. On the basis of the original oral medication, one group (treatment group) received dextrins injected before going to bed, the other group (control group) Glargard injection at bedtime, observed for 12 weeks. Results: FBG, 2hPG and HbA1c decreased. There was no significant difference between the two groups (P> 0.05) in terms of the time required for reaching the blood glucose level, the daily insulin dosage and the incidence of hypoglycemia. CONCLUSION: Dextrins and glargine are equally safe and effective in controlling type 2 diabetes mellitus.