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目的探讨替吉奥联合奥沙利铂治疗晚期胃癌的有效性。方法晚期胃癌患者43例为研究对象,采用回顾性研究,依照患者体表面积采用替吉奥和奥沙利铂分别用药,根据疾病控制情况分析疗效。结果治疗后,患者完全缓解(CR)为11.63%,部分缓解(PR)为44.19%,病情稳定(SD)为20.93%,病情进展(PD)为23.26%,有效率(RR)为55.82%,疾病控制率(DCR)为76.75%。无治疗相关性死亡,且无患者因出现IV度不良反应、不能耐受化疗毒性反应而终止治疗,研究中发现的不良反应主要为:呕吐、恶心、腹泻等消化道反应,血小板、中性粒细胞、血红蛋白的减少,外周神经(感觉/运动神经)毒性和肝脏毒性(转氨酶升高)等。结论采用替吉奥联合奥沙利铂作为化疗药物治疗晚期胃癌的有效率较高,不良反应可以耐受,值得临床推广应用。
Objective To investigate the efficacy of tioguanide combined with oxaliplatin in the treatment of advanced gastric cancer. Methods Forty-three patients with advanced gastric cancer were studied retrospectively. The patients were treated with tioguanide and oxaliplatin respectively according to their body surface area, and the curative effect was analyzed according to the disease control. Results After treatment, the complete remission (CR) was 11.63%, the partial remission (PR) was 44.19%, the stable condition (SD) was 20.93%, the disease progression was 23.26%, the effective rate was 55.82% The disease control rate (DCR) was 76.75%. No treatment-related deaths, and no patient due to the emergence of IV degrees of adverse reactions, can not tolerate the toxicity of chemotherapy and termination of treatment, the adverse reactions found in the study are: vomiting, nausea, diarrhea and other gastrointestinal reactions, platelets, neutrophils Reduction of cells, hemoglobin, peripheral nerve (sensory / motor nerve) toxicity and hepatotoxicity (elevated aminotransferases), and the like. Conclusion The use of TIGO combined with oxaliplatin as a chemotherapy drug in the treatment of advanced gastric cancer is more effective and the adverse reactions can be tolerated, which is worthy of clinical application.