东方神丹对脑老化的影响

• 作 者: 叶智文 肖军军 李英姿 陈雨亭 尹广大
• 机 构: 北京医科大学细胞生物教研室
• 出 处: 中日友好医院学报
• 发表日期: 1996年02期
• 关键词: 脑老化 脂褐质颗粒 神丹 老年大鼠 大鼠药 补肾中药 自由基作用 自由基理论 苏丹黑 药对

为探讨补肾中药东方神丹对脑老化有无改善作用，观察了该药对老年大鼠某些脑区脂褐质的含量以及超氧化物歧化酶（ＳＯＤ）活性的影响及该药体外清除自由基的作用。结果表明：老年鼠海马锥体细胞的脂褐质蓄积明显多于年青鼠（Ｐ＜００１），如以５００个细胞计算，脂褐质占细胞质面积＞１／２的细胞占３６４％，而年青组未见此类细胞。喂服东方神丹后可明显减少老年大鼠下丘脑和海马脑区的脂褐质沉积（Ｐ＜００１），明显提高下丘脑ＳＯＤ活性（Ｐ＜００１），同时药物本身也有较强的清除自由基作用，说明东方神丹有延缓脑老化的作用

In order to investigate the effect of Bushen Chinese medicine Shenandoan on the aging of the brain, the effects of the medicine on the content of lipofuscin and the activity of superoxide dismutase (SOD) The role of base. The results showed that the accumulation of lipofuscin in hippocampal pyramidal neurons in aged rats was significantly more than that in young rats (P <001). For 500 cells, the percentage of cells with cytoplasmic area> 1/2 accounted for 364 %, While no such cells in the young group. Oral administration of Shen-Dan could significantly reduce the lipofuscin deposition in the hypothalamus and hippocampus of aged rats (P <001), and significantly increase the activity of hypothalamic SOD (P <001) Strong role in the removal of free radicals, indicating that the East God Shendan has the role of delaying brain aging