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目的 以不同浓度氯化钙、氯化镁静脉滴注，观察钙、镁对大肺、脑血管缺氧损害的保护作用。为钙、镁制剂的临床应用提供依据。方法 用低氧复制犬的动物缺氧模型，采用氯化钙、氯化镁每ｍｉｎ０．５ｍｇ／ｋｇ对犬连续滴注５ｈ，在用药前后测定缺氧犬血液动力学指标及血气分析。结果 氯化钙与氯化镁 ０．５ｍｇ／ｋｇ组急性肺泡缺氧时，血液动力学参数肺血管阻力变化率（ＡＰＶＲ）与对照组相比显著降低（Ｐ＜０．０１），体血管阻力变化率（△ＳＶＲ）及脑血流量变化率（△ＣＢＦ）与对照组相比有显著差异（Ｐ＜０．０５）；肺动脉平均压升压反应（△Ｐｐａ）和体动脉压（△Ｐｓａ）以及心输出量（△ＣＯ）无明显改变。结论 氯化钙与氯化镁联合应用可提高降低缺氧性肺、脑血管阻力，降低缺氧性肺动脉高压的药物疗效；减少高浓度镁对心率、血压、心肌的不利影响；减少高浓度钙增加血液粘滞度及对心脏的不利影响，且可减少钙制剂和镁制剂的单独用药的剂量，提高疗效。
Objective To different concentrations of calcium chloride, magnesium chloride intravenous infusion of calcium and magnesium on the lung, cerebral vascular hypoxic damage protection. Calcium, magnesium preparations provide the basis for clinical application. Methods Hypoxia model of animal hypoxia was used. Dogs were instilled with 0.5 mg / kg of calcium chloride and magnesium chloride continuously for 5 hours. The hemodynamic indexes and blood gas analysis of hypoxic dogs were determined before and after treatment. Results Compared with the control group, the changes of hemodynamic parameters of pulmonary vascular resistance (APVR) in calcium chloride and magnesium chloride 0.5mg / kg group were significantly lower than those in control group (P <0.01), the rate of change of vascular resistance (△ SVF) and the rate of change of cerebral blood flow (△ CBF) were significantly different from those in the control group (P <0.05); the mean pulmonary arterial pressure response (△ Ppa) and body fluid pressure (△ Psa) Output (△ CO) no significant change. Conclusion Combined use of calcium chloride and magnesium chloride can improve the hypoxic pulmonary and cerebral vascular resistance and reduce hypoxic pulmonary hypertension drug efficacy; reduce high concentrations of magnesium on the adverse effects of heart rate, blood pressure, myocardial; reduce the high concentration of calcium to increase blood Viscosity and adverse effects on the heart, and can reduce the dosage of calcium preparations and magnesium preparations alone to improve the efficacy.