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抗酸剂能改变药物分子的离子化状态,阻滞胃排空,改变体液的pH、吸附药物而改变药物的吸收速率,除影响生物利用度外,会在治疗中带来严重的后果。作者以美国药典19版转篮溶出仪研究了在各含1%三硅酸镁、氧化镁、氢氧化铝、碳酸镁、碳酸钙粉的介质中,对醋磺环己脲、甲磺氮(艹卓)脲、甲磺丁脲片溶出的影响。结果:氧化镁、氢氧化铝、碳酸钙、碳酸镁使三种片剂的溶出呈较小增加(0.5—1小时),然后是轻微减低的平稳状态(1—3小时),三硅酸镁中度减低了三种片剂的溶出速率,溶液中3小时后的甲磺丁脲量以不含抗酸剂时作100%相比,含碳酸钙、
Antacids can change the ionization state of drug molecules, retard gastric emptying, change the pH of body fluids, and change the absorption rate of drugs by adsorbing drugs. In addition to affecting bioavailability, it can have serious consequences in the treatment. The author of the United States Pharmacopoeia 19 rotating basket dissolution instrument studied in each containing 1% magnesium trisilicate, magnesium oxide, aluminum hydroxide, magnesium carbonate, calcium carbonate powder medium, the vinegar sulfonylureas, mesotrione艹 Zhuo) urea, methamphetamine tablets dissolution of the impact. Results: Magnesium oxide, aluminum hydroxide, calcium carbonate, magnesium carbonate gave a slight increase in dissolution (0.5-1 hour) for the three tablets followed by a slightly reduced plateau (1-3 hours), magnesium trisilicate Moderately reduced the dissolution rate of three tablets, the amount of metoxicamide in the solution after 3 hours was 100% compared to that without antacid,