论文部分内容阅读
自1953年,从类癌瘤中分离出5-羟色胺(5-HT)后,即认为对血管具有药理作用的这一物质系造成类癌潮红的原因。事实上并非如此简单。临床所见潮红有4种类型:1)主要累及面、颈、前上胸,常可延及背、腹、掌,呈短暂发作,持续2～5分钟;2)范围如上,呈紫色而持续时间较长。平时鼻发亮而呈紫色。尿液中5-HIAA通常很高;3)伴发于支气管类癌,潮红可持续数小时甚至一天,皮肤红中带紫,范围广,伴有流泪及结膜充血,脸面水肿皮纹加深;4)潮红为鲜红色呈斑状分布,尤以颈根部为突出,常伴发于胃类癌及产组织胺过多者。不同类型潮红肯定有不同的药理学机制。静注5-HT并不产生真正的类癌样潮红,潮红时动脉血桨中5-
Since 1953, serotonin (5-HT) has been isolated from carcinoid tumors, a substance that is believed to have a pharmacological effect on blood vessels that contributes to the carcinoid flushing. In fact it is not so simple. There are 4 types of clinically seen flushing: 1) mainly involving the face, neck, anterior upper chest, often extended to the back, abdomen, palm, was a brief attack, sustained 2 to 5 minutes; 2) range above, purple and continued A long time. Usually shiny nose and purple. Urine 5-HIAA is usually high; 3) associated with bronchial carcinoid, flushing can last for several hours or even one day, the skin red with purple, a wide range, accompanied by tearing and conjunctival congestion, facial edema dermatoglysmic; 4 ) Fluorescent bright red spotted distribution, especially in the prominent neck, often accompanied by stomach cancer and the production of histamine too much. Different types of flushing certainly have different pharmacological mechanisms. Intravenous 5-HT does not produce true carcinoid-like flushing, flushing when the arterial blood 5-