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目的：探讨了COPD患者治疗前后血清NGF、TNFα和IL-18水平的变化及临床意义。方法：应用放射免疫法和酶联法对35例COPD患者进行了治疗前后血清NGF、TNFα和IL-18水平检测，并与30名正常健康人作比较。结果：COPD患者在治疗前血清NGF、TNFα和IL-18水平均非常显著地高于正常人组（p＜0.01），经治疗一个月后则与正常人比较无显著性差异（p＞0.05），且血清NGF水平与TNFα、IL-18水平呈显著正相关（r=0.5928,0.6122，p＜0.01）。结论：检测血清NGF、TNFα和IL-18水平的变化对探讨其发病机制、提供了有价值的实验室依据。“,”Objective To explore The clinical Significance of Changes of Serum NGF、TNFα and IL-18 levels after treatment in patients With COPD.Methods Serum TNFα(With RIA),Serum NGF、IL-18 (With ELISA) levels were determined in 35 patients With COPD and 30 controls.Results Before treatment, Serum NGF、TNFα and IL-18 levels were Significantly higher than those in Controls(p0.05).Serum NGF level expersed positively correlated With Serum TNFα、IL-18 levels(r=0.5928、0.6122,p<0.01).Conclusions Detection of Serum NGF、TNFαand IL-18 levels after treatment provides a valuable taboratory basis for the explortion of the pathogenesis in COPD.