论文部分内容阅读
一、尿激酶的作用机理尿激酶是日本发明的一种纤溶活性药物。它是由人尿精制而成的,但没有抗原性,不含热源物质,因此欧美正在以此代替链激酶。尿激酶溶解血栓的机理是:血液中的纤维蛋白溶酶原和注入的尿激酶、链激酶等进入血栓后,生成纤维蛋白溶酶从而溶解血栓。当血栓变陈旧时,血栓中纤维蛋白溶酶原含量即随之低下,加上尿激酶不易进入血栓,因此随着血栓形成时间的延长越发难以溶解(经过三天以上的血栓很难溶解),因此越早应用尿激酶效果越好。
First, the mechanism of action of urokinase Urokinase is a fibrinolytic active drug invented in Japan. It is refined from human urine, but no antigenicity, does not contain heat source material, so Europe and the United States is being replaced by streptokinase. Urokinase thrombolytic mechanism is: blood in the plasminogen and injected urokinase, streptokinase into the thrombus, the formation of plasmin to dissolve the thrombus. Thrombosis become old, the thrombus in the plasminogen content that is accompanied by low, coupled with urokinase is not easy to enter the thrombus, so as thrombosis time more difficult to dissolve (after more than three days of thrombosis is difficult to dissolve) Therefore, the sooner the application of urokinase effect is better.