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目的检测男性及绝经期女性肺癌患者外周血性激素水平并探讨其对肺癌诊断、治疗的价值。方法采用化学发光免疫分析技术测定98例肺腺癌患者(27例术前患者、42例术后患者、29例术后化疗后患者)、30例肺良性病患者和30例健康人血清中雌二醇及睾酮水平,并探讨治疗手段对血清性激素的影响。结果与对照组相比,各组肺癌患者T水平降低,E2水平和E2/T明显升高;与术后患者相比,肺癌术前组T水平降低(P<0.05),E2水平和E2/T统计学升高(P<0.01);而术后化疗前后肺癌组患者E2水平、E2/T、T水平无统计学差异(P>0.05)。男性及绝经期女性患者E2水平、E2/T比值无明显差异(P>0.05)。结论男性及绝经后女性肺癌患者血清中存在性激素代谢的失衡与紊乱,检测肺腺癌患者血清E2、T水平和E2/T对肺癌的诊断具有一定的辅助价值;化疗不能改变肺癌患者的内分泌紊乱,可能需要相应的内分泌治疗。
Objective To detect the levels of serum sex hormones in male and postmenopausal women with lung cancer and to explore its value in the diagnosis and treatment of lung cancer. Methods Chemiluminescent immunoassay was used to detect the serum levels of 98 cases of lung adenocarcinoma (27 cases of preoperative, 42 cases of postoperative chemotherapy, 29 cases of postoperative chemotherapy), 30 cases of benign lung disease and 30 cases of healthy female Diol and testosterone levels, and explore the treatment of serum sex hormones. Results Compared with the control group, the levels of T, E2 and E2 / T in lung cancer patients in each group were significantly lower than those in the control group (P <0.05). The levels of E2 and E2 / (P <0.01). There was no significant difference in E2 level, E2 / T level and T level before and after chemotherapy in lung cancer patients (P> 0.05). There was no significant difference in E2 level and E2 / T ratio between men and menopausal women (P> 0.05). Conclusions There is an imbalance and disorder of sex hormone metabolism in the serum of male and postmenopausal women with lung cancer. Detecting serum levels of E2 and T and E2 / T in patients with lung adenocarcinoma has some auxiliary value in the diagnosis of lung cancer. Chemotherapy can not change the endocrine disorders in patients with lung cancer , May require appropriate endocrine therapy.