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目的评估盐酸氨溴索联合沙丁胺醇雾化吸入治疗毛细支气管炎的效果。方法选择2009年2月—2011年6月收治的毛细支气管炎患儿86例,随机分为治疗组46例和对照组40例。两组患儿均给予常规治疗(抗感染、吸氧、气道管理、止咳等)。在此基础上治疗组给予盐酸氨溴索注射液15 mg和沙丁胺醇2.5 mg加生理盐水3 ml氧气驱动雾化吸入,2次/d;对照组给予沙丁胺醇2.5 mg加生理盐水3 ml氧气驱动雾化吸入,2次/d。结果总有效率治疗组97.83%,对照组87.50%,两组比较差异有统计学意义(P<0.05)。且两组临床表现消失时间及住院时间比较差异均有统计学意义(均P>0.05)。结论盐酸氨溴索联合沙丁胺醇雾化吸入治疗毛细支气管炎疗效显著,可缩短病程。
Objective To evaluate the efficacy of ambroxol hydrochloride combined with salbutamol inhalation in the treatment of bronchiolitis. Methods 86 cases of bronchiolitis admitted from February 2009 to June 2011 were randomly divided into treatment group (46 cases) and control group (40 cases). Two groups of children were given conventional treatment (anti-infection, oxygen, airway management, cough, etc.). On this basis, the treatment group was given ambroxol hydrochloride injection 15 mg and salbutamol 2.5 mg plus saline 3 ml oxygen inhalation, 2 times / d; the control group was given salbutamol 2.5 mg plus normal saline 3 ml oxygen-driven atomization Inhaled, 2 times / d. Results The total effective rate was 97.83% in the treatment group and 87.50% in the control group, with significant difference between the two groups (P <0.05). There were significant differences between the two groups in the disappearance of clinical manifestations and the length of hospital stay (all P> 0.05). Conclusion Ambroxol hydrochloride combined with salbutamol inhalation treatment of bronchiolitis significant effect, can shorten the course.