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随着社会的发展和人民生活水平的不断提高,人们的饮食与生活习惯都发生了巨大的变化。伴随发生的是人群肥胖、高脂血症和2型糖尿病(T2DM)等代谢性疾病的发病率迅速上升且患病人群年轻化,严重威胁着人类的健康和生活质量[1]。最新研究显示,代谢性疾病的发生及发展不仅受遗传因素控制,还受环境因素导致的表观遗传修饰改变的影响。
With the development of society and continuous improvement of people’s living standards, people’s diet and living habits have undergone tremendous changes. Accompanying is the rapid increase in the incidence of obesity, hyperlipidemia and type 2 diabetes mellitus (T2DM) and other metabolic diseases and the rejuvenation of the affected population, which seriously threaten human health and quality of life [1]. Recent research shows that the occurrence and development of metabolic diseases are not only controlled by genetic factors, but also by the environmental factors that lead to changes in epigenetic modifications.