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在清醒兔心肌缺血再灌注损伤模型,50mg/kg和100mg/kg三七总皂甙(PNGS)能明显减少心电图缺血性改变,使再灌注期间CPK活性不出现进一步升高。在PNGS处理组,结扎冠脉后和再通后的LD活性明显低于对照组。PNGS明显缩小心肌缺血区面积。提示PNGS具有保护心肌缺血再灌注损伤的作用。
In the model of myocardial ischemia-reperfusion injury in awake rabbits, 50mg / kg and 100mg / kg PNGS can significantly reduce the ischemic changes of ECG, so that CPK activity does not appear to increase further during reperfusion. In the PNGS-treated group, the LD activity after coronary artery ligation and recanalization was significantly lower than that of the control group. PNGS significantly reduced myocardial ischemic area. Tip PNGS has a protective effect of myocardial ischemia-reperfusion injury.