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作为继P53、PRb之后重要的抑癌基因,PTEN(phosphatase and tensin hemology deleted on chromosometen)的研究已成为肿瘤学研究的热点。已有研究报道了PTEN+/-小鼠易发生自发性血液系统肿瘤[1]。现对PTEN抑癌基因与血液系统恶性肿瘤关系的新近研究进展作一综述。1 PTEN基因结构
As an important tumor suppressor gene following P53 and PRb, the research on PTEN (phosphatase and tensin hemology deleted on chromosome chromosome) has become a hot topic in oncology research. It has been reported that PTEN +/- mice are prone to spontaneous hematological malignancies [1]. The recent progress on the relationship between PTEN tumor suppressor gene and hematological malignancies is reviewed. 1 PTEN gene structure