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从70年代初就对肺结核短程化疗做了大量研究,本文复习了一些公认的重要内容,并对进一步研究方向加以讨论。[药物作用机制] Grosset(1978)总结了用鼠进行实验的一些资料,其要点是:①吡嗪酰胺与利福平是很有效的杀菌剂;②最有效的杀菌剂联用是异烟肼加吡嗪酰胺和异烟肼加利福平;③加入链霉素或乙胺丁醇对上述两种杀菌剂联用的杀菌能力实际上没有增强作用。Mitchison(1980)指出在人的病灶中有四种菌群:一个是可被杀菌剂杀灭的生长较快的菌群。如果单独使用抗结核药,异烟肼杀菌活性较高,利福平较低,链霉素和吡嗪酰胺更低。但这些药物与异烟肼联用,则有最高的杀
Since the early 1970s, a great deal of research has been done on short-course chemotherapy for pulmonary tuberculosis. This article reviews some important and important contents and discusses the further research directions. [Mechanisms of drug action] Grosset (1978) summarizes some of the data used in experiments with rats. The main points are: (1) pyrazinamide and rifampicin are very effective bactericides; (2) the most effective bactericide is isoniazid Plus pyrazinamide and isoniazid plus rifampin; ③ adding streptomycin or ethambutol in combination with the above two fungicides bactericidal capacity actually did not enhance the role. Mitchison (1980) points out that there are four types of flora in a human lesion: one is a rapidly growing population that can be killed by a bactericide. If anti-tuberculosis drugs alone, isoniazid bactericidal activity is higher, lower rifampicin, streptomycin and pyrazinamide lower. However, these drugs combined with isoniazid, the highest kill