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目的:探讨联合应用激素、美沙拉嗪、甲硝唑及奎诺酮类药物与激素加柳氮磺胺吡啶治疗中重度溃疡性结肠炎的疗效,比较其复发率,找出最佳治疗方案。方法:选择中重度溃疡性结肠炎病例42例,分为治疗组与对照组。治疗组26例,应用激素、美沙拉嗪、甲硝唑及喹诺酮类药物联合治疗,对照组16例,应用激素、柳氮磺胺吡啶联合治疗。复查电子结肠镜判断两组患者的疗效及预后。结果:治疗组有效率为96.15%,复发率为7.69%,对照组有效率为75%,复发率为12.5%,两组疗效比较,P<0.05,治疗组与对照组疗效有显著差异,复发率比较,P>0.05,治疗组与对照组无显著差异。结论:对照组获缓解或有效,总有效率较对照组高(P<0.05),两组复发率比较,无显著性差异(P>0.05)。说明在治疗中重度溃疡性结肠炎时,为取得更佳的疗效,合理、联合、持续应用激素、美沙拉嗪、甲硝唑及奎诺酮类药物是关键。
OBJECTIVE: To investigate the curative effect of combined application of hormones, mesalazine, metronidazole and quinolones and hormone plus sulfasalazine in the treatment of moderate-to-severe ulcerative colitis. Compare the relapse rate and find out the best treatment plan. Methods: 42 cases of moderate-severe ulcerative colitis were selected and divided into treatment group and control group. Treatment group of 26 cases, the application of hormone, mesalazine, metronidazole and quinolones combined treatment, control group of 16 patients, the application of hormone, sulfasalazine combination therapy. Review of electronic colonoscopy to determine the efficacy and prognosis of two groups of patients. Results: The effective rate of the treatment group was 96.15%, the recurrence rate was 7.69%, the effective rate of the control group was 75%, the recurrence rate was 12.5%, the curative effect of the two groups was significantly lower than that of the control group Rate comparison, P> 0.05, no significant difference between the treatment group and the control group. Conclusion: The control group was relieved or effective, and the total effective rate was higher than that of the control group (P <0.05). There was no significant difference between the two groups (P> 0.05). Description of the treatment of severe ulcerative colitis, in order to achieve better efficacy, rational, combined, continuous application of hormones, mesalazine, metronidazole and quinolones is the key.