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目的：探讨内皮素（ＥＴ－１）和一氧化氮（ＮＯ）代谢产物在蛛网膜下腔出血（ＳＡＨ）后症状性脑血管痉挛（ＳＣＶＳ）发生机制中的作用。方法：建立兔的症状性脑血管痉挛模型，观察ＳＡＨ后不同时间血浆和脑脊液（ＣＳＦ）中ＥＴ－１和 ＮＯ代谢产物含量变化。结果：ＳＡＨ后第４天和第７天血浆和ＣＳＦ中ＥＴ－１含量均显著升高（Ｐ＜０．０１），且以ＳＡＨ后第４天为著。ＳＡＨ后第４天和第７天血浆和ＣＳＦ中ＮＯ代谢产物含量也明显升高（Ｐ＜０．０１），但二者之间无显著性差异（Ｐ＞０．０５）。结论：ＳＡＨ后血浆和ＣＳＦ中ＥＴ－１和ＮＯ代谢产物含量增加可能在ＳＣＶＳ发生机制中起重要作用。
Objective: To investigate the role of endothelin (ET-1) and nitric oxide (NO) metabolites in the pathogenesis of symptomatic cerebral vasospasm (SCVS) after subarachnoid hemorrhage (SAH). Methods: The model of symptomatic cerebral vasospasm in rabbits was established. The changes of ET-1 and NO metabolites in plasma and cerebrospinal fluid (CSF) at different time points after SAH were observed. Results: The levels of ET-1 in plasma and CSF were significantly increased on the 4th and 7th days after SAH (P <0.01), and on the 4th day after SAH. The content of NO metabolites in plasma and CSF at 4 and 7 days after SAH was also significantly increased (P <0.01), but there was no significant difference between the two (P> 0.05). Conclusion: The increase of ET-1 and NO metabolites in plasma and CSF after SAH may play an important role in the pathogenesis of SCVS.