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对子宫内膜分泌不良的不孕妇女分别使用雌、孕激素类药物治疗31例(A组),单独使用孕激素治疗32例(B组),观察用药前后子宫内膜雌激素受体(ER)含量及组织学变化。结果表明,A组用药后ER含量明显增加(P<0.05),且组织学变化接近正常周期内膜或与其同步。而B组用药前后ER含量及组织学观察均无明显变化(P>0.05),部分病例ER含量有下降趋势。提示:对ER含量低下的子宫内膜发育不良患者,合理使用雌、孕激素类药物治疗,可提高靶细胞的受体含量、使内膜发育得到改善,是治疗不孕症的环节之一。
Infertility endometrial infertility women were treated with estrogen and progesterone drugs in 31 cases (group A), with progesterone alone in 32 cases (group B), before and after treatment to observe the endometrial estrogen receptor (ER ) Content and histological changes. The results showed that the ER content in group A increased significantly (P <0.05), and histological changes were close to or synchronized with the normal endometrium. However, there was no significant change in ER content and histological examination before and after treatment in group B (P> 0.05), and the ER content in some cases showed a downward trend. Tip: ER levels of endometrial dysplasia patients, the rational use of estrogen and progesterone drugs can increase the target cell receptor content, so that the development of the intima is improved, is one of the links in the treatment of infertility.