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目的探讨C反应蛋白、降钙素原和D-二聚体水平检测在急性白血病诊疗中的临床价值。方法选取2014年12月—2015年6月于广西桂东人民医院收治的急性白血病患者40例作为研究组,另选本院同期40例体检的健康者作为对照组,比较两组C反应蛋白、降钙素原和D-二聚体水平。结果研究组C反应蛋白、降钙素原和D-二聚体水平均高于对照组,差异有统计学意义(P<0.05);其中急性淋巴细胞白血病(ALL)与急性非淋巴细胞白血病(ANLL)患者三项检测指标比较差异无统计学意义(P>0.05)。40例急性白血病患者三项检测指标阳性率分别为90.0%(36/40)、70.0%(28/40)、75.0%(30/40),后期治疗过程中细菌性感染三项检测者指标水平高于非细菌性感染者,差异有统计学意义(P<0.05)。结论 C反应蛋白、降钙素原和D-二聚体检测水平能够反映急性白血病患者机体感染和纤溶系统状况,为临床病情评估和具体用药提供参考依据。
Objective To investigate the clinical value of C-reactive protein, procalcitonin and D-dimer in the diagnosis and treatment of acute leukemia. Methods Forty patients with acute leukemia who were treated in Guidong People’s Hospital of Guangxi from December 2014 to June 2015 were selected as the study group and 40 healthy people in the same period of the hospital were selected as the control group.The C reactive protein, Procalcitonin and D-dimer levels. Results The levels of C-reactive protein, procalcitonin and D-dimer in the study group were significantly higher than those in the control group (P <0.05). The levels of C-reactive protein, procalcitonin and D-dimer in the study group were significantly higher than those in the control group ANLL) patients had no significant difference in the three detection indexes (P> 0.05). The positive rates of the three detection indexes in 40 cases of acute leukemia were 90.0% (36/40), 70.0% (28/40) and 75.0% (30/40) respectively. The indexes of the three tests of bacterial infection during the later period of treatment were Higher than non-bacterial infection, the difference was statistically significant (P <0.05). Conclusion The detection of C-reactive protein, procalcitonin and D-dimer can reflect the status of infection and fibrinolytic system in patients with acute leukemia and provide reference for clinical evaluation and specific medication.