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目的探讨心肌肌钙蛋白I(cTnl)、肌红蛋白(MB)和肌酸激酶同工酶(CK-MB)对急性心肌梗死(AMI)诊断的临床价值。方法对136例AMI患者于胸痛发作后24 h内检测血清中cTnI、MB和CK-MB水平,比较这3项指标对AMI诊断的敏感性和特异性。结果急性AMI患者的cTnI、MB、CK-MB检测结果分别为(1.29±0.93)、(426±214)、(23.7±17.8)μg/L,较正常对照组均有显著性升高(P<0.05)。cTnl、MB、CK-MB对AMI的敏感性分别为97.1%、98.5%和77.9%,特异性分别为97.7%、87.8%和95.0%。结论急性AMI患者的cTnI、MB、CK-MB的值均明显升高。3项指标在AMI诊断中具有较高的灵敏度和特异性,其中以cTnI最佳。3项指标联合检测效果更好,在AMI的诊断中起到重要作用。
Objective To investigate the clinical value of cTnl, myoglobin (MB) and creatine kinase MB (CK-MB) in the diagnosis of acute myocardial infarction (AMI). Methods Serum levels of cTnI, MB and CK-MB were measured in 136 patients with acute myocardial infarction (AMI) within 24 hours after the onset of chest pain. The sensitivity and specificity of these three parameters in the diagnosis of AMI were compared. Results The results of cTnI, MB and CK-MB in acute AMI patients were (1.29 ± 0.93), (426 ± 214) and (23.7 ± 17.8) μg / L respectively, which were significantly higher than those in normal controls (P < 0.05). The sensitivity of cTnl, MB and CK-MB to AMI was 97.1%, 98.5% and 77.9% respectively, and the specificity was 97.7%, 87.8% and 95.0% respectively. Conclusions The values of cTnI, MB and CK-MB in acute AMI patients were significantly increased. Three indicators in the diagnosis of AMI with high sensitivity and specificity, of which cTnI best. Three indicators of joint detection better, in the diagnosis of AMI play an important role.