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目的:观察中西医结合治疗联合护理干预抑郁症患者的疗效及安全性。方法:选取140例肝郁脾虚型抑郁症患者作为研究对象,并随机分入观察组和对照组各70例。对照组采用氢溴酸西酞普兰片治疗,观察组在对照组治疗基础上服用逍遥丸。2组均采用相同的护理方法。观察比较2组患者治疗后的病情改善情况、本次发作病程、1年内复发情况和和药物不良反应情况。结果:观察组患者的抑郁程度低于对照组,平均汉密尔顿抑郁量表(HAMD)评分低于对照组,差异均有统计学意义(P<0.01)。观察组本次发作平均病程短于对照组,差异有统计学意义(P<0.01)。观察组1年内复发次数和平均复发病程均少/短于对照组,差异均有统计学意义(P<0.01)。不良反应发生率观察组为4.55%,对照组为6.35%,2组比较,差异无统计学意义(P>0.05)。结论:应用逍遥丸与氢溴酸西酞普兰治疗联合护理干预肝郁脾虚型抑郁症患者,可以显著提高疗效,缩短病程,并降低复发率,且无明显不良反应,是一种安全有效的治疗方法。
Objective: To observe the efficacy and safety of integrated traditional Chinese and western medicine in the treatment of depression patients with combined nursing. Methods: 140 cases of depression with liver depression and spleen deficiency syndrome were selected as research object and randomly divided into observation group and control group with 70 cases each. The control group was treated with citalopram hydrobromide. The observation group was given Xiaoyao Pill on the basis of the control group. Both groups used the same method of care. Observation and comparison of two groups of patients after treatment to improve the condition, the course of this attack, recurrence within 1 year and adverse drug reactions. Results: The depression degree of the observation group was lower than that of the control group. The mean Hamilton Depression Rating Scale (HAMD) score was lower than that of the control group (P <0.01). The observation group the average duration of this episode was shorter than the control group, the difference was statistically significant (P <0.01). The frequency of recurrence and the average recurrence rate in the observation group were both less and shorter than those in the control group within one year (P <0.01). The incidence of adverse reactions was 4.55% in the observation group and 6.35% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion: The combination of Xiaoyao Pills and citalopram hydrobromide in the treatment of depressive patients with liver depression and spleen deficiency can significantly improve the efficacy, shorten the course of disease, and reduce the recurrence rate, and no obvious adverse reactions, is a safe and effective treatment method.