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目的探讨容积旋转调强技术配合新辅助化疗在乳腺癌患者中的应用效果。方法选取2013年6月至2015年3月间山东省德州市第二人民医院收治的54例乳腺癌患者,采用随机数表法分为研究组和对照组,每组27例,研究组患者采用容积旋转调强技术联合新辅助化疗治疗,对照组患者采用新辅助化疗治疗。观察比较两组患者的治疗效果、不良反应情况、三年内的局部复发及生存情况。结果研究组患者临床获益率为66.7%显著高于对照组的29.6%,差异有统计学意义(P<0.05)。两组患者不良发生率比较,差异无统计学意义(P>0.05)。研究组患者三年局部复发率为7.4%显著低于对照组患者的29.6%,差异有统计学意义(P<0.05)。研究组患者三年生存率为66.7%显著高于对照组患者的40.7%,差异有统计学意义(P<0.05)。结论容积旋转调强技术配合新辅助化疗能够显著提高乳腺癌患者治疗效果及生存率,降低局部复发率。
Objective To investigate the effect of volume rotation intensity-modulated technique combined with neoadjuvant chemotherapy in patients with breast cancer. Methods From June 2013 to March 2015, 54 cases of breast cancer admitted to the Second People’s Hospital of Dezhou, Shandong Province were divided into study group and control group by random number table, with 27 cases in each group. The study group was treated with Volume rotation intensity modulation technology combined with neoadjuvant chemotherapy, the control group of patients with neoadjuvant chemotherapy. The therapeutic effects, adverse reactions, local recurrence and survival within three years were observed and compared between the two groups. Results The clinical benefit rate of study group was 66.7%, which was significantly higher than that of control group (29.6%), the difference was statistically significant (P <0.05). There was no significant difference in adverse incidence between the two groups (P> 0.05). The three-year local recurrence rate was 7.4% in the study group, which was significantly lower than that in the control group (29.6%, P <0.05). The three-year survival rate of the study group was 66.7%, which was significantly higher than that of the control group (40.7%), the difference was statistically significant (P <0.05). Conclusion Volume rotation IMRT combined with neoadjuvant chemotherapy can significantly improve the treatment effect and survival rate of patients with breast cancer and reduce the local recurrence rate.