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为检验“人类1、9、16号染色体C带多态现象的体细胞嵌合状态可能源于有丝分裂交换”这一假说,作者将5名正常男性的外周血淋巴细胞用丝裂霉素C处理,证明丝裂霉素C能改变异染色质的模式.一般报道认为,C显带的结构异染色质多态性在一个个体内是一种稳定的特征.但是有些报道指出,人类1、9、16号染色体C带区存在体细胞嵌合状态,新变异产生的最可能的解释是由于体细胞交换.已知丝裂霉素C可诱发低等真核生物的体细胞交换和培养的人类成纤维细胞1号染色体的C带交
To test the hypothesis that the somatic chimerism of human chromosome C polymorphism on chromosomes 1, 9 and 16 may be due to mitotic exchange, the authors used 5 normal male peripheral blood lymphocytes with mitomycin C treatment to prove that mitomycin C can change heterochromatin mode.Generally reported that C-banding structural heterochromatin polymorphism is a stable feature in an individual.But some reports indicate that human 1 , The C-band of chromosomes 9 and 16 present somatic chimerism and the most likely explanation for the new mutation is due to somatic exchange It is known that mitomycin C can induce somatic exchange and culture of lower eukaryotes Of the human Fibroblast Chromosome 1 C-band