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痤疮是一种慢性皮肤病，多以粉刺，丘诊，脓疱，结节，囊肿及瘢痕为特征。其病因以雄激素分泌过多为主要作用，米诺环素为广谱抗生素，对痤疮杆菌有较强的抑制作用，并能在皮脂腺中达到有效抗菌浓度。己烯雌酚为人工合成雌激素，有抵消雄激素作用，有嫩肤，减轻皮肤过度角化作用。而异维A酸是维生素A的衍生物，局部外用无效，内服可抑制皮脂腺功能，并能使皮肤上痤疮丙酸杆菌明显减少。但本品的副作用较大，可致皮肤干燥，瘙痒，脱屑，暂时脱发，少数有关节肌肉痛，有疲劳厌食等，本品并有畸作用。己烯雌酚可通过皮肤、粘膜及皮下肌肉吸收，脂溶性好。据此，应用己烯雌酚外用，而不是口服，药物直接针对皮肤，直接对靶细胞，不但吸收好，而且减少了因内服对人体的抗雄性激素作用，减少对内分泌的影响。本品还有嫩肤减少皮肤角化作用，改善毛囊及皮脂腺的角化及导管异常，减少皮脂排泄障碍，减少丙酸杆菌繁殖赖以生存的环境，从而减少了炎症及炎症介质的产生。与对照引比较，优势明显，价廉，副作用少，值得推广。“,”The acne is a chronic skin disease, with acne, Qiu diagnosis, pustules, nodules, cysts and scars characteristics. The cause of the excessive secretion of androgens as the main role, minocycline as broad-spectrum antibiotics, has a strong inhibitory effect on acne bacilus, and can achieve effective antibiotic concentration in sebaceous gland. For the synthetic estrogen diethylstilbestrol, counteract the androgen action, have tender skin, relieve skin hyperkeratosis effect. Different dimension A acid is a vitamin A derivative, topical invalid, oral administration can inhibit the sebaceous gland function, and can make the skin P.acnes significantly reduced. But the side effects of this product is larger, can cause dry skin, itching, desquamation, temporary hair loss, there are a few joint and muscle pain, fatigue anorexia, this product and the distortion effect. Diethylstilbestrol can be absorbed through the skin, mucosa and muscle, fat soluble. Therefore, the application of diethylstilbestrol external, not oral, drugs directly to the skin, directly on the target cel, not only of good absorption, but also reduces the oral administration of anti androgen effect on human body, reduce the impact on the endocrine. This product is also reduce hyperkeratotic skin rejuvenation, improve the diagonalization and catheter hair folicle and sebaceous gland abnormalities, reduce sebum excretion barriers, reduction of Propionibacterium reproductive survival environment, thereby reducing the generation of mediators of inflammation and inflammation. Cheap and control the comparison, obvious advantages,, less side effect, is worth promoting.