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目的探讨米非司酮配伍依沙吖啶终止14~24周妊娠的疗效。方法选择孕14~24周自愿要求终止妊娠的健康女性160例,随机分为两组。观察组:米非司酮75mg,1次/d,共2d,同时配伍0·5%依沙吖啶100mg羊膜腔内注射。对照组:单用0·5%的依沙吖啶100mg羊膜腔内注射。结果两组用药至分娩的时间,总产程比较差异有统计学意义(P<0·05)。产后出血量、胎盘胎膜残留、软产道损伤、清宫率比较差异有统计学意义(P<0·05)。而用药至宫缩时间、引产成功率比较差异无统计学意义(P>0·05)。结论米非司酮配伍依沙吖啶引产具有成功率高、产程短、软产道损伤小、清宫率低等优点,值得临床推广。
Objective To investigate the efficacy of mifepristone combined with ethacridine in the termination of 14-24 weeks gestation. Methods A total of 160 healthy women who volunteered for termination of pregnancy at 14-24 weeks’ gestation were randomly divided into two groups. Observation group: mifepristone 75mg, 1 time / d, a total of 2d, while compatible with 0-5% Ethacridine 100mg amniotic cavity injection. Control group: single 0.5% Ethacridine 100mg intra-amniotic injection. Results The duration of labor and labor between the two groups were statistically significant (P <0.05). Postpartum hemorrhage, placental residual membrane, soft birth canal injury, clearance rate difference was statistically significant (P <0. 05). The medication to the time of contractions, the success rate of induction of labor was no significant difference (P> 0.05). Conclusion Mifepristone compatibility ethacridine induction of labor has the advantages of high success rate, short delivery, soft birth canal injury, low rate of cure, worthy of clinical promotion.