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应用酶联免疫方法对７５例正常人，８０例行血液透析治疗的尿毒症患者血清心肌特异性肌钙蛋白Ｔ（ｃＴｎＴ）进行检测，并同时观察肌酸激酶（ＣＫ）、肌酸激酶－ＭＢ亚单位（ＣＫ－ＭＢ）水平。结果显示：正常人血清ｃＴｎＴ浓度极低，５６例ｃＴｎＴ测定值为０，最高值为００３μｇ／Ｌ。尿毒症患者血清ｃＴｎＴ测定范围０００～３９４μｇ／Ｌ，其中３４例（４２５％）血清ｃＴｎＴ浓度＞０．２μｇ／Ｌ（阳性界限值），范围０２２～３．９４μｇ／Ｌ，增加１１～１９７倍，仅３例患者同时伴ＣＫ、ＣＫ－ＭＢ升高。血清ｃＴｎＴ升高与尿素氮（ＢＵＮ）、肌酐（Ｃｒ）无相关性。研究提示：ｃＴｎＴ升高的尿毒症患者可能伴有急性心肌细胞损伤，其中部分患者可能存在急性粟粒样或小灶状心肌梗塞。血清ｃＴｎＴ测定对诊断尿毒症合并心肌损伤较ＣＫ、ＣＫ－ＭＢ具有更高的灵敏性和特异性。
Enzyme-linked immunosorbent assay was used to detect serum cardiac troponin T (cTnT) in 75 normal subjects and 80 hemodialysis patients with uremia. The levels of creatine kinase (CK), creatine kinase-MB Subunit (CK-MB) levels. The results showed that the normal serum cTnT concentration is very low, 56 cases of cTnT measured value of 0, the highest value of 0 03μg / L. The range of serum cTnT in patients with uremia was 000 ~ 394μg / L, in which 34 cases (425%) had serum cTnT concentration> 0.2μg / L (positive limit), the range of 022 ~ 3.94μg / L, increased 1 1 ~ 19 7 times, only 3 patients accompanied by CK, CK-MB increased. Serum cTnT increased with urea nitrogen (BUN), creatinine (Cr) no correlation. Research suggests that patients with elevated cTnT may have acute cardiomyocyte damage, some of whom may have acute miliary or focal dementia. Serum cTnT determination of uremia diagnosis of myocardial injury than CK, CK-MB has a higher sensitivity and specificity.