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This study was to evaluate effect of ~(125)I brachytherapy combined with chemotherapy on advanced non-small cell lung cancer(NSCLC). Patients with NSCLC in stages III to IV were divided into two groups: Group A(n = 27) received ~(125)I brachytherapy combined with gemcitabine and cisplatin(GP) chemotherapy, and Group B(n = 27) received GP chemotherapy only. The results showed that the overall response rate and median progression-free survival time were 78% and 11.5 months in Group A, 41% and 8 months in Group B, respectively(P < 0.05). For Group A, the 1- and 2-years survival rates were 67% and 37%, respectively,with the median survival time of 16 months, whereas the corresponding data of Group B were 48%, 22% and 11.5 months(P > 0.05). The interventional complications in Group A included 5 patients with postoperative pneumothorax and 4 patients with hemoptysis. No patients had radiation pneumonia, radiation esophagitis or esophagotracheal fistula. Chemotherapy treatment-related toxicities were not significantly different between the two groups. The relief of tumor-associated symptoms including cough, hemoptysis, chest pain, and short breath was found in both groups, without statistical difference in remission rates between Groups A and B(P > 0.05).In conclusion, ~(125)I brachytherapy combined with chemotherapy proved to be safe and effective for treating advanced NSCLC with few complications. It improves local control rate and prolongs the progression-free survival time.
This study was to evaluate the effect of ~ (125) I brachytherapy combined with chemotherapy on advanced non-small cell lung cancer (NSCLC). Patients with NSCLC in stages III to IV were divided into two groups: Group A (n = 27) received (125) I brachytherapy combined with gemcitabine and cisplatin (GP) chemotherapy, and Group B (n = 27) received GP chemotherapy only. The results showed that the overall response rate and median progression-free survival time were 78% and 11.5 months for Group A, the 1- and 2-year survival rates were 67% and 37%, respectively, with the median survival time of 16 months in Group A, 41% and 8 months in Group B, respectively (P <0.05) , the corresponding data of Group B were 48%, 22% and 11.5 months (P> 0.05). The interventional complications in Group A included 5 patients with postoperative pneumothorax and 4 patients with hemoptysis. No patients had radiation pneumonia, radiation esophagitis or esophagotracheal fistula. Chemotherapy treatment-related toxicit The relief of tumor-associated symptoms including cough, hemoptysis, chest pain, and short breath was found in both groups, without statistical difference in remission rates between Groups A and B (P> 0.05) In conclusion, ~ (125) I brachytherapy combined with the study proved to be safe and effective for treating advanced NSCLC with few complications. It improves local control rate and prolongs the progression-free survival time.