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茶碱和β肾上腺素能激动剂常合用于支气管哮喘的治疗。β_2肾上腺素激动剂间羟舒喘灵与茶碱合用,对支气管扩张的相加作用是肯定无疑的,但也有认为两药合用会增加副作用和死亡率。作者对12例7～11岁支气管哮喘患儿进行了随机双盲交叉试验,以观察间羟舒喘灵对茶碱血清浓度和疗效的影响。其方法是给患者服用茶碱缓释片10mg/kg bid,连服6周。在用药2、3周或第5、6周加服间羟舒喘灵醑剂0.075/kg,tid。对照组使用等量的安慰剂。治疗期间测定血清中茶碱浓度,观察各项临床指征,测定最大呼气流量,并比较单用茶碱和加用间羟舒喘灵后的不同效应。
Theophylline and beta adrenergic agonists are often used in the treatment of bronchial asthma. Beta 2 adrenergic agonist hydroxytheptolide and theophylline combination of bronchodilator additive effect is certain, but there are also that the two drugs will increase side effects and mortality. The author of 12 children aged 7 to 11 years with bronchial asthma in a randomized double-blind crossover test to observe the role of interstrahydro hydroxylase on theophylline serum concentration and efficacy. The method is to give patients taking theophylline sustained-release tablets 10mg / kg bid, even for 6 weeks. In the medication for 2,3 weeks or 5,6 weeks plus the amount of hydroxylase hydrochloride tablets 0.075 / kg, tid. The control group used the same amount of placebo. Determination of serum theophylline concentration during treatment to observe the clinical indications, the maximum expiratory flow was measured, and compared with single theophylline and add with different after the effect of isoquascin.