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目的：探讨阿奇霉素在小儿肺炎中的药代学特征，据此拟订其用于肺炎患儿的给药方案。方法100例肺炎患儿口服阿奇霉素（10mg/kg）后，以高效液相色谱法（HPLC）测定患儿体内的血药浓度，采用AIC法结合F检验判别房室模型，DAS药动学程序计算药动学参数。结果药代学符合二室模型（Wi=1/C2，AIC=-7.0296），主要药动学参数为：α=（0.31±0.07）/h，β=（0.05±0.01）/h，Ka=（0.76±0.18）/h，t1/2β=（42.37±9.23）/h，tmax=（4.13±0.62）/h， Cmax=（318.72±36.51）μg/L，AUC0-144=（22.38±3.14）μg·h/ml，AUC0-∞=（24.66±3.27）μg·h/ml。结论肺炎患儿口服阿奇霉素后有典型的药代学特征，对指导临床给药具有重要的意义。“,”Objective To investigate the azithromycin in children with pneumonia in the pharmacokinetic characteristics,according to the dosing regimen for children with pneumonia.Methods 100 cases of pneumonia in children with oral azithromycin (10mg/kg),with high performance liquid chromatography (HPLC) determination of drug concentration in blood in patients with F test,discriminant compartmental model using AIC pharmacokinetic program,the pharmacokinetic parameters were calculated by DAS medicine.Results The pharmacokinetics was consistent with two compartment model (Wi=1/C2, AIC=-7.0296),as the main drug pharmacokinetics parameters:a=(0.31±0.07)/h,β=(0.05± 0.01)/h,Ka=(0.76 ± 0.18)/h,t1/2β=(42.37 ± 9.23)/h,tmax=(4.13 ± 0.62)/h,Cmax=(318.72 ± 36.51)μg/L,AUC0-144=(22.38 ± 3.14)μg·h/ml, AUC0-∞=(24.66 ± 3.27)μg·h/ml.Conclusion Pneumonia after oral azithromycin pharmacokinetics characteristics of typical medicine,the administration has an important significance in guiding clinical.