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目的 探讨氧化苦参碱治疗慢性乙型肝炎肝纤维化的效果及其机制。方法 5 8例慢性乙型肝炎伴肝纤维化病人随机分为治疗组 (2 8例 )和对照组 (30例 )。治疗组给予氧化苦参碱每日 6 0 0mg静脉注射 ,对照组给予维生素类一般保肝药 ,疗程 3个月。结果 治疗组治疗第 1个月末血清丙氨酸氨基转移酶 (ALT)复常率高于对照组 (P <0 0 5 ) ,但第 2个月末、治疗结束时两组复常率间差异无显著意义。治疗组治疗结束时血清转化生长因子 β1、透明质酸 (HA)、Ⅲ型前胶原 (PCⅢ )、Ⅳ型胶原 (ⅣC)和层粘蛋白 (LN)水平较治疗前显著下降 (分别为P <0 0 1,P <0 0 5 ) ,对照组治疗前后血清TGFβ1、HA、PCⅢ、ⅣC和LN水平差异无显著意义 (均为P >0 0 5 )。结论 氧化苦参碱有减轻乙型肝炎肝纤维化的作用。
Objective To investigate the effect and mechanism of oxymatrine on chronic hepatitis B liver fibrosis. Methods Fifty-eight patients with chronic hepatitis B and liver fibrosis were randomly divided into treatment group (28 cases) and control group (30 cases). The treatment group was given oxymatrine daily 600mg intravenous injection, the control group was given vitamin general liver medicine, treatment for 3 months. Results The normalization rate of alanine aminotransferase (ALT) in the treatment group at the end of the first month of treatment was higher than that in the control group (P <0 05). However, there was no significant difference between the two groups at the end of the second month Significant. Serum levels of transforming growth factor β1, hyaluronic acid (HA), type Ⅲ procollagen (Ⅲ), type Ⅳ collagen (ⅣC) and laminin were significantly decreased at the end of treatment in the treatment group (P < There was no significant difference in serum levels of TGFβ1, HA, PCⅢ, ⅣC and LN between the two groups before and after treatment (all P 0 05). Conclusion Oxymatrine can reduce hepatitis B liver fibrosis.