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目的 :观察实验性糖尿病大鼠腹腔内移植海藻酸钠微囊化成猪胰岛治疗效果。方法 :以海藻酸钠一多聚赖氨酸作为制备微囊的材料 ,将 18只糖尿病大鼠随机分为 3组 :对照组、未微囊化胰岛移植组、微囊化胰岛移植 ,分别进行腹腔内胰岛移植。结果 :移植前 3组血糖水平无显著差异 ,移植后 7d时 ,3组血糖分别为 2 2 6 7± 1 15mmol/L ,18 5 8± 2 6 2mmol/L和13 5 7± 1 88mmol/L ,微囊化胰岛移植组与前 2组相比均有显著差异 ,且生存期明显长于前 2组。结论 :海藻酸钠微囊化成猪胰岛可存活于糖尿病大鼠体内 ,并且具有有效生物活性。
Objective : To observe the therapeutic effect of intraperitoneal transplantation of sodium alginate microencapsulated into porcine islets in experimental diabetic rats. METHODS: Sodium alginate-polylysine was used as the material for preparation of microcapsules. Eighteen diabetic rats were randomly divided into three groups: control group, non-microencapsulated islet transplantation group, and microencapsulated islet transplantation. Intraperitoneal islet transplantation. Results: There was no significant difference in blood glucose levels between the 3 groups before transplantation. On the 7th day after transplantation, the blood glucose levels in the 3 groups were 2 2 7 7 1 15 mmol/L, 18 5 8± 2 6 2 mmol/L and 13 5 7± 1 88 mmol/L, respectively. In the microencapsulated islet transplantation group, there were significant differences compared with the first two groups, and the survival period was significantly longer than the first two groups. Conclusion: Microencapsulation of sodium alginate into porcine islets can survive in diabetic rats, and has effective biological activity.