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目的:建立一测多评法测定香砂六君丸中两种木香内酯类成分的HPLC分析方法,更有效控制其质量。方法:以木香烃内酯为内标,建立其与去氢木香内酯的相对校正因子,用HPLC法进行含量测定,计算木香烃内酯、去氢木香内酯的含量,对“一测多评”法的计算值与外标法实测值进行比较。结果:建立的相对校正因子重复性良好,采用相对校正因子计算的含量与外标法实测值基本一致。结论:“一测多评”法可用于香砂六君丸中木香内酯类成分的含量测定,方法可靠、结果准确,能有效控制该制剂质量。
OBJECTIVE: To establish a HPLC method for the determination of two woody lactones in Xiangsha Liujun pill by multiple evaluation method, and to control its quality more effectively. Methods: To determine the relative correction factors of dehydrolalignam with woodlocolactone as internal standard, and to determine the content of woodlocolactone and dehydrocostuslactone by HPLC. “One test more than one evaluation ” The calculated value of law and external standard method to compare the measured value. Results: The relative correction factor was established with good reproducibility. The content calculated by relative correction factor was basically consistent with the measured value of external standard method. CONCLUSION: The “one test multiple evaluation” method can be used to determine the content of luxiang lactones in Xiangsha Liujun pill. The method is reliable, the result is accurate and the quality of the preparation can be controlled effectively.