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已有研究表明,Cr(VI)对大鼠、豚鼠有毒性及诱变作用。为探讨维生素C和E在其中的作用,作者进行了下述两个实验。实验1 选取雄性Wistar大鼠36只,体重120～140g,随机分成6组,每组6只。第1组和第2组为对照组,两周内腹腔注射生理盐水6次;3～6组为Cr(VI)中毒组,以与对照组相同的方式腹腔注射K_2Cr_2O_7溶液,剂量12mg/kg体重。第2、4、6组动物用α-生育酚灌胃,每次20mg/kg体重,每周5次,连续2周。第5、6组动物在给K_2Cr_2O_7,同时
It has been reported that Cr (VI) is toxic and mutagenic in rats and guinea pigs. To explore the role of vitamins C and E in them, the authors conducted the following two experiments. In experiment 1, 36 male Wistar rats weighing 120-140 g were randomly divided into 6 groups with 6 rats in each group. Group 1 and group 2 were control group, intraperitoneal injection of normal saline 6 times within two weeks; group 3 to 6 were Cr (VI) poisoning group, intraperitoneal injection of K 2 Cr 2 O 7 solution in the same way as the control group, dose 12 mg / kg body weight . Groups 2, 4 and 6 were orally administered with α-tocopherol, each 20 mg / kg body weight, 5 times a week for 2 weeks. Group 5,6 animals to K_2Cr_2O_7, at the same time